DUSP4 expression was positive in 2 cases (8.7%) of normal colorectal tissue and 2 cases (4.0%) of tubular adenoma; however, DUSP4 expression was positive in 166 cases (37.8%) of adenocarcinoma, 19 cases (33.9%) of lymph node metastasis, and 32 cases (60.4%) of distant metastasis (Table 1). The gene discussed is DUSP4; the disease is metastatic malignant neoplasm in the lymph nodes.