In this study, we investigated DUSP4 expression in 23 samples of normal colorectal tissue, 50 samples of tubular adenoma, 439 samples of adenocarcinoma, 56 samples of lymph node metastasis, and 53 samples of distant metastasis and evaluated the correlation between DUSP4 expression and clinicopathological parameters and patient survival in patients with colorectal adenocarcinoma. The gene discussed is DUSP4; the disease is metastatic malignant neoplasm in the lymph nodes.