CDKN1A and Werner syndrome: The results demonstrated that in addition to the CDKI genes p21Cip1/Waf1 and p16INK4A, the SASP genes such as IL-6, gp130, IGFBP5, IGFBP7, ANGPTL2, and TIMP1 were highly expressed in cells of patients with WS as compared with PDL-matched normal fibroblasts.