Indeed, BAT is now known to exert anti-type 2 diabetic effects associated with improvments of dyslipidemia and insulin secretion as well as decrease insulin resistance in type 2 diabetes (de Souza et al., 1997; Liu et al., 1998; Frontini et al., 2013; Peirce and Vidal-Puig, 2013). Here, INS is linked to type 2 diabetes mellitus.