AGTR1 and Hypertension: Angiotensin converting enzyme 2, a zinc carboxypeptidase (Donoghue et al., 2000; Tipnis et al., 2000; Turner et al., 2002), the AT1R and the AT2R and their Ang II-derived ligands are all involved in modulating hypertension (Donoghue et al., 2000; Tipnis et al., 2000; Turner et al., 2002; Jiang et al., 2014).