NRG1 and Anxiety: It should be noted that a series of control experiments regarding normal profiles of basic behavioral phenotypes was reported previously in Akt1+/− or Akt1−/– mice (Lai et al., 2006; Chen and Lai, 2011; Chen et al., 2012, 2014) and in Nrg1+/− mice (Pei et al., 2014), such as locomotor activity, anxiety-like behavior, olfactory function, and sensorimotor gating function.