Interestingly, our results indicated that deletion of sEH did not influence the development of glomerulosclerosis, which is a common feature of chronic kidney disease and subsequent renal dysfunction; this result was consistent with the previous findings by Jung et al. that sEH inhibition does not prevent progression of renal glomerulosclerosis in the progressive renal disease model [19]. The gene discussed is EPHX2; the disease is glomerulosclerosis.