Parametric polar maps and histogram analysis allowed fast, reproducible and straightforward interpretation (Fig. 18), with differentiation of TTR (transthyretin) amyloidosis (with low but increased uptake), light-chain precursor kappa amyloidosis (with moderately elevated uptake) and light-chain lambda fragment amyloidosis (with very high global or regional uptake). The gene discussed is TTR; the disease is amyloidosis.