ELISA assay with sera from the colon cancer patients revealed that levels of shed syndecan-2 in the sera were 625.9 ng/ml (range 321.2–863.6 ng/ml) in advanced colon cancer patients, whereas those of the sera from healthy people (N) was 176.3 ng/ml (range 87.4–431.0 ng/ml; Figure 5C). Here, SDC2 is linked to malignant colon neoplasm.