As to the relationship between SNAI2 and NED-related gene expression, a total positive correlation emerged between the expression of SNAI2 and CHGA in clinical high-grade PCa samples, since all the 13 CHGA-positive NED areas also expressed SNAI2, whereas the 54 CHGA-negative high-grade PCa lacked SNAI2 expression (apart from the tumor burden) (Figure 3A and 3C). Here, SNAI2 is linked to posterior cortical atrophy.