Our data reveal that, in addition to the canonical cadherin switch, represented by the opposite E-Cadh/N-Cadh expression, and Cyclin D1 regulation, which confirms its influence on the cell cycle [25], SNAI2 heavily affects the expression of the neural tissue associated adhesion molecules N-Cadh 2 and Nr-CAM both critically involved in cell migration and invasion and strongly down-regulated in PCa cells following SNAI2 silencing. Here, NRCAM is linked to posterior cortical atrophy.