The Chromogranin-A (CHGA) positive NED areas (13 PCa samples containing NED areas), which may develop in conventional adenocarcinomas (~10% frequency), especially within high-grade PCa (our observation and ref. 13), were marked by SNAI2 expression (Figure 3C), whose strength ranged from distinct to strong and involved nearly all cancer cells. Here, SNAI2 is linked to adenocarcinoma.