The mean level of SNAI2 mRNA of malignant stroma was not significantly different from that of the normal counterpart, whereas it was considerably (p < 0.05) down-regulated in the neoplastic epithelial cell populations from both low- (~14 times) and high- (~16 times) grade PCa (with no appreciable difference between them) (Figure 1A), in comparison with the normal epithelium. The gene discussed is SNAI2; the disease is posterior cortical atrophy.