NOTCH1 and posterior cortical atrophy: SNAI2 gene dramatically modulates three key regulators of the cell stem state, associated with invasion and metastasization, namely CD44v6 [28, 29], SOX2 [30–34] and NOTCH1 [35–38], as revealed by both SNAI2 silencing and over-expression experiments, in PCa cells in vitro and, probably, in PCa tissue in vivo.