CHGA and adenocarcinoma: The Chromogranin-A (CHGA) positive NED areas (13 PCa samples containing NED areas), which may develop in conventional adenocarcinomas (~10% frequency), especially within high-grade PCa (our observation and ref. 13), were marked by SNAI2 expression (Figure 3C), whose strength ranged from distinct to strong and involved nearly all cancer cells.