SNAI2 and cancer: To assess whether SNAI2 may affect PCa cell malignancy by regulating other gene pathways besides those tightly associated with EMT, we next investigated the expression, in SNAI2 knockdown PC3 cells, of a set of metastasis-suppressor [17, 18] and pluripotency genes which have been associated with cancer aggressiveness and metastatic potential [11, 12].