Human LYRMs are linked with diseases, such as insulin-resistance (LYRM1 [9]), muscular hypotonia (LYRM3 [10]), deficiency of multiple OXPHOS complexes (LYRM4 [11]), apoptosis in HIV-1 infection (LYRM6 [12]), encephalopathy and lactic acidosis (LYRM7/MZM1L [13]), infantile leukoencephalopathy (LYRM8/succinate dehydrogenase assembly factor (SDHAF) 1 [14]) and alcohol dependence (acetate non-utilizing protein (ACN) 9/SDHAF3 [15]). The gene discussed is LYRM7; the disease is HIV-1 infection.