EGFR and lung adenocarcinoma: It is also required for upper aerodigestive tractdevelopment, and is known to be amplified in a subset of esophageal and squamous lungcancers, although it has not been previously implicated in lung adenocarcinomas,including the subset driven by mutant EGFR (Elliset al., 2004; Gontan et al., 2008;Bass et al., 2009).