SOX2 was also not induced in other oncogene-dependentmodels, such as ALK-translocated lung cancer cells treated withcrizotinib, HER2-amplified breast cancer cells exposed to lapatinibor BRAF-mutant melanoma cells treated with AZD6244 (Figure 1A and Figure 1—figure supplement 2B). The gene discussed is ALK; the disease is lung carcinoma.