Forinstance, acute loss of ERK signaling triggered by RAF or MEK inhibitors inBRAF mutant melanoma cells relieves ERK-dependent inhibition of RASand CRAF, whose activation through ErbB receptor signaling may lead to paradoxicalproliferative signals (Pratilas et al., 2009;Paraiso et al., 2010; Lito et al., 2012). Here, RAF1 is linked to melanoma.