All FOXO proteins bind to similar DNAsequences, with isoform-specific activity presumably conferred by cellular andpromoter context (Furuyama et al., 2000).Indeed, all four FOXO isoforms are expressed in EGFR-mutant lung cancer cells,transcriptionally induced following EGFR inhibition and phosphorylated at homologousSerine residues, yet only FOXO6 regulates SOX2 in these cells. The gene discussed is SOX2; the disease is lung cancer.