The direct binding bySOX2 of the BIM and BMF genes is consistent withthe ability of the four reprogramming factors (SOX2, OCT-4, KLF-4, and c-MYC) to bindto the promoters of several anti-apoptotic genes (including BMF) which are inducedearly during the reprogramming process (Kim et al.,2008; Soufi et al., 2012).Interestingly, control of SOX2 expression and its modulation of apoptosis may differin EGFR-mutant lung cancer, compared with other forms of NSCLC. This evidence concerns the gene POU5F1 and non-small cell lung carcinoma.