Thus,SOX2 was strongly induced in three mutant EGFR-addicted lung cancer cell lines(HCC827, PC9, H3255) following treatment with physiologically relevant concentrationsof erlotinib (0.1 μM), but not when these cells were treated with comparablyeffective doses of cytotoxic chemotherapy (Figure1A,B and Figure 1—figuresupplement 2A). The gene discussed is EGFR; the disease is lung cancer.