In PC9 mutant, EGFR-addicted lung cancer cells, EGFR inhibitiontriggers apoptosis in the vast majority of cells in vitro, uncovering approximately 0.3%that are drug tolerant, quiescent, and expressing the stem cell marker CD133 and thehistone H3K4 demethylase KDM5A (Sharma et al.,2010). The gene discussed is EGFR; the disease is lung cancer.