The HCC2935 human lung cancer cellline is remarkable for harboring a characteristic oncogene-addicting EGFR mutation(exon 19 deletion) yet having unexplained resistance to erlotinib (Figure 8A), including absence of the common T790Mgatekeeper mutation within EGFR and no amplification of the MET bypass signalingpathway (Zheng et al., 2011). Here, EGFR is linked to lung carcinoma.