AKT1 and neoplasm: It is also noteworthy that biological therapeutics may be used to enhance anti-tumor activity, because the cytotoxic activity of γδ T cells was significantly augmented by a conformational change in γδ TCR complexes induced by a certain monoclonal antibody against CD3 and the subsequent signal transduction through PI3K/Akt and Ras/Ark pathways [53].