The main findings of the study are summarized as follows: (i) Qmax⁡ and PSA are not good indicators for progression of BPH; (ii) VDR gene FokI SNPs may be a molecular markers which is associated with progression of BPH; (iii) genotype “ff” is likely to develop BPH progression. This evidence concerns the gene KLK3 and benign prostatic hyperplasia.