3.2. Coexpression of Tim-3 and PD-1 Correlates with More Severe Exhaustion of T Cells during HIV Infection, and Simultaneous Blockade of Tim-3 and PD-1 Pathways Synergistically Restores T-Cell Secretion of IFN-γ or IL-2. This evidence concerns the gene HAVCR2 and HIV infectious disease.