In bivariate cox proportional hazard model, the predictor variables that showed significant (P < 0.05) association with the outcome variable were marital status, occupational status, educational status, the base line and follow-up functional status, having exposure for prophylaxis at baseline and adhering to it both at baseline and at follow up, baseline hemoglobin value, follow-up CD4 count, follow-up body mass index, number of OIs diagnosed at one time at start of the study, and being diagnosed wasting syndrome and Herpes Zoster at start of study (Table 3). This evidence concerns the gene CD4 and Cachexia.