After adjustment for potential confounders in multivariate cox proportional hazard model, the significant (P < 0.05) predictors preventing repeated diagnosing of OI rediagnosis were being employed in governmental or private sectors, divorced than married, taking prophylaxis at baseline, having a follow-up CD4 count above 100 cells/μL, and having hemoglobin value of 10 g/dl and above, whereas not adhering to prophylaxis both at base line and at follow-up was the risk factors for short time rediagnosing of OIs (Table 3). Here, CD4 is linked to osteogenesis imperfecta.