However, the mechanism of coupled dynamics transfer (caused by ligand binding, for example) over large distances (>10 Å, spanning multiple bond lengths) remains unknown, and determining this mechanism is a fundamental pursuit of structural biology.4 We utilize graph theoretical methods to determine the coupling between regions that mediates dynamics transfer and apply our methodology to rescue cystic fibrosis-causing mutants of the protein CFTR. Here, CFTR is linked to cystic fibrosis.