DPYSL2 and myocardial infarction: To investigate the effect of CRMP2 knockdown on infarct healing in ApoE−/− mice with MI, we used a lipidoid nanoparticle to deliver CRMP2 siRNA into the wound because employing the endocytic machinery of macrophages, intravenously administered nanoparticles are rapidly taken up by monocytes/macrophages, and accumulated in macrophages in atherosclerotic plaques [36,37], rendering inflammatory myeloid cells a prime target for in vivo RNAi [38-40].