However, the treatment of melanoma cells with Wnt5a led to a redistribution of CD146 into a polarised structure at the tail end of the cells; further assembly occurred between actin and myosin II with CD146 to form the Wnt5a-mediated receptor –actin – myosin polarity (WRAMP) structure [17,19-21]. The gene discussed is WNT5A; the disease is melanoma.