To elucidate the mechanism of angiogenesis in human melanoma, a recent report found that overexpression of endogenous p50, a member of the NF-κB family, significantly enhanced interleukin-6 (IL-6)-induced endothelial cell growth in vitro and promoted human melanoma angiogenesis in vivo (Figure 4) [72,73]. The gene discussed is IL6; the disease is melanoma.