Moreover, elimination of CD146 can significantly ameliorate the severity of inflammation, in murine models of colitis [24], as well as in experimental autoimmune encephalomyelitis [28]; Suppression of CD146 can also decreased the tumour incidence and tumour progression in a murine model of colitis-associated colorectal carcinogenesis [24]. This evidence concerns the gene MCAM and experimental autoimmune encephalomyelitis.