Overexpression of MTDH has been observed in multiple types of cancer, including breast cancer (3,8), hepatocellular carcinoma (5), human glioma (20), neuroblastoma (7,21), esophageal cancer (22), non-small-cell lung cancer (23), cervical cancer (24) and PC (11–12). Here, MTDH is linked to hepatocellular carcinoma.