Herein we took advantage of previously characterized artificial TFs targeting the SOX2 promoter made of six zinc finger (6ZF) domains, recognizing 18 base pair (bp) sites in the core promoter.17 These 6ZFs were linked to the catalytic domain of DNA methyltransferase 3A (DNMT3A), an enzyme that catalyzes de novo DNAme, to correct the aberrant methylation state of SOX2 in cancer cells. The gene discussed is DNMT3A; the disease is cancer.