DNMT3A and neoplasm: Over the period of 43 days, a significant inhibition (P=0.0001) of tumor growth was detected in animals injected with ZF598-DNMT3A receiving a Dox-containing diet (Figure 3b, right panel), which was superior to the inhibition we have reported for Krueppel-associated box-containing repressors.17 Furthermore, this reduction of tumor growth was maintained up to 72 days after Dox induction (P=0.001).