Kobayashi et al (17) demonstrated that knockdown of Brachyury increases the sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vivo; therefore, Brachyury may be involved in the regulation of cell cycle progression, which alters the therapeutic effects of conventional cancer treatments, including chemotherapy, radiotherapy and immune therapy. This evidence concerns the gene TBX1 and adenoid cystic carcinoma.