For ESCC, seven SNPs in PLCE1 were significantly related with ESCC risk, exceeding the Bonferroni-corrected threshold, which was previously identified by the initial GWAS; and a further five SNPs in INPP4B (rs336407, rs336298, rs3775692 and rs336332) and INPP5A (rs10747068) with P < 0.001 (Supplementary Table SI). This evidence concerns the gene INPP5A and esophageal squamous cell carcinoma.