14, 15; http://www.cbioportal.org). A number of mouse glioma models have been generated by overexpressing secreted PDGF ligands in the brain (for review, see Refs. 16, 17), but since secreted PDGF ligands may act through both autocrine and paracrine mechanisms, the cell of origin cannot be conclusively defined in these glioma models. These models also do not address the prevalence of PDGFRA gene amplification and its oncogenic role in gliomagenesis. Here, PDGFRA is linked to central nervous system cancer.