To generate a glioma mouse model based on cell-autonomous activation of PDGFRα in OPCs, we utilized mice that carry conditional knock-in alleles of PDGFRα with the point mutations V561D (termed J for “juxtamembrane”) or D842V (termed K for “kinase domain”)18, 20 (Fig. 1a). The gene discussed is PDGFRA; the disease is glioma.