However, particularly in brain, a combined use of anti-VEGFR-2 compounds and chemotherapy may exert adverse effects, and has not translated into convincing clinical results proving prolonged overall survival [32, 33], largely due to its controversially discussed effects on the tumor vasculature leading to alterations in blood flow, oxygenation status, and delivery of concurrent chemotherapy, i.e., the role of vessel pruning vs. normalization. The gene discussed is KDR; the disease is neoplasm.