We further examined the expression of RasGRP3 in GBM by using the REMBRANDT (Repository of Molecular Brain Neoplasia Data) data portal and found that intermediate levels of RasGRP3 were significantly (p < 0.005) associated with a worse clinical outcome compared to tumors with downregulated levels of this protein (Fig. 1G). Here, RASGRP3 is linked to glioblastoma.