No Annexin-V positivity, caspase 3 cleavage or LC3 conversion was detected indicating neither induction of apoptotic nor autophagic cell death upon in vivo treatment (FIGURE 4I, J, K; SUPPLEMENTARY FIGURE 5), in line with our results on primary and cell line BCP-ALL. The gene discussed is CASP3; the disease is acute lymphoblastic leukemia.