LDLR and familial hyperaldosteronism: However, if the true frequency of FH in the UK is similar to the 1/250 reported in Denmark [1], with this estimate supported by the frequency of 1/217 of LDLR mutation carriers observed by exome sequencing [22], our overall detection rate would be only 35% (i.e. 7 of the 20 expected in the 5000 subjects examined).