Increased expression of Sulf1 and Sulf2 in some cancers, including pancreatic adenocarcinomas (Nawroth et al., 2007) and non-small cell lung cancers (Lemjabbar-Alaoui et al., 2010) is associated with overactive Wnt signalling. The gene discussed is SULF2; the disease is pancreatic adenocarcinoma.