Previous studies have shown that androgen signaling, mediated by the androgen receptor (AR), has a role in all phases of PCa, including CRPC (Arnold & Isaacs, 2002; Shen & Abate-Shen, 2010; Dayyani et al, 2011; Yap et al, 2011; Bluemn & Nelson, 2012). This evidence concerns the gene AR and posterior cortical atrophy.