Information on the time until onset of allergic reactions after food allergen intake (minutes–hours vs hours–days) and allergy phenotype (eg, urticaria vs atopic dermatitis) can help to determine whether the symptoms involve immediate IgE-mediated mast cell or basophil activation, or late-phase or chronic allergic inflammation caused by T-cell or eosinophil activation. Here, IGHE is linked to allergic disease.