Multisystem involvement (involving at least 2 systems) of CMV EODs was found in 67.6% (50 of 74) amongst the subjects having CD4<30 cells/μl who had developed CMV EOD/s—37.8% (28/74) had CMV induced GIT diseases along with retinitis while 22.9% (17/74) had developed pulmonary diseases along with retinitis. Here, CD4 is linked to digestive system disorder.