Individuals with FXS demonstrate generally exaggerated responses to sensory stimuli [9] and unusual cortical activity in response to sound [11–13, 15, 34] In addition to increased responses to sensory stimuli, findings from pre-pulse inhibition testing show both individuals with FXS and Fmr1-/- mice experience deficits in sensorimotor gating [41, 42]. This evidence concerns the gene FMR1 and fragile X syndrome.