PIK3CA and glioblastoma: Those genes include EGFR, PDGFRA, FGFR3, PIK3CA, MDM4, CDKN2A/B, PTEN and are all members of the core alterated pathways in glioblastoma controlling key phenotypes such as proliferation, apoptosis and angiogenesis (Fig. 3, [3,35,40,41]).