Since VEGF plays an important role in the in the pathogenesis of intraocular neovascular diseases such as exudative age-related macular degeneration and proliferative diabetic retinopathy, one may assume that the physiologically lower intraocular concentration of VEGF in myopic eyes versus hyperopic eyes may be one of the reasons for the lower prevalence of age-related macular degeneration and diabetic retinopathy in myopic eyes [8–17]. The gene discussed is VEGFA; the disease is age-related macular degeneration.