Our study did not find an association between the SNPs tagging HLA-DRB-1 and CAC. In concordance with our other findings, there are reports of no association between genetic variants in genes regulating IL-1, interferon-gamma, toll like receptor-4, and IL-6 and atherosclerosis in RA [26,27,28,29]. This evidence concerns the gene TLR4 and rheumatoid arthritis.