TNFRSF11B and coronary atherosclerosis: Of all the variants initially associated with the presence of coronary atherosclerosis, rs2073618, which encodes an Asn3Lys missense change in the osteoprotegerin gene (TNFRSF11B), was most highly associated with the presence of coronary artery calcium (CAC) (OR = 4.09, p = 0.00026).