Interestingly, although both types of GP vaccinated mice demonstrated strong recall response against GP33 (~1000 fold increase for Ad-GP vs. ~200 fold increase for Ad-IiGP on day 10 post infection, and 228 vs. 29 fold on day 60 post infection, respectively), vaccination with Ad-NP and Ad-IiGP in combination resulted in much less pronounced expansion of GP33 specific CD8+ T cells as compared to that in Ad-GP or Ad-IiGP vaccinated mice (66 fold expansion on day 10 post infection and 5 fold on day 60 post infection. The gene discussed is CD8A; the disease is infection.