KIT and gastrointestinal stromal tumor: Moreover, an NDI derivative (i) is able to strongly stabilize G-quadruplex sequences located both at telomeric ends and at the promoter region of oncogenes like c-KIT; (ii) it induces a suppression of KIT mRNA and protein expression in patient-derived gastrointestinal stromal tumors, thus representing an alternative promising approach for the treatment of human gastrointestinal stromal cancer [13].