Moreover, thiazolidinediones (TZDs), such as pioglitazone (PIO), modulate specific facets of the MetS [20,21] via enhanced transcriptional activation of PPAR-γ to mediate their antihyperglycemic, antihypertensive, antihyperlipidemic, antioxidant, and anti-inflammatory properties [22–26]. This evidence concerns the gene PPARG and metabolic syndrome.