Effect of 4 weeks daily oral administration of geraniol (GO; 250 mg/kg), pioglitazone (PIO; 5 and 10 mg/kg), and GO with PIO5 on plasma serum fasting blood glucose and insulin levels, as well as homeostatic model assessment-insulin resistance (HOMA-IR), McAuley index, and quantitative insulin sensitivity check index (QUICKI) in fructose-induced metabolic syndrome (MetS) in rats. This evidence concerns the gene INS and Insulin resistance.