CXCR4 and metastatic malignant neoplasm in the lymph nodes: CXCR4 expression was significantly associated with lymph node metastasis (P = 0.001), and EGFR/CXCR4 coexpression was significantly associated with lymph node metastasis (P = 0.026), TNM stage (P = 0.048), and poor tumor differentiation (P = 0.004) (Table 2).