Acute myeloid leukemia with the gene rearrangement t (8; 21) (q22; q22); (AML1/ETO), which is also referred to as the RUNX1 gene, and AML with the rearrangement t (15; 17) (q22; q12) (PML/RARα) are considered distinct AML subtypes. The gene discussed is PML; the disease is acute myeloid leukemia.