非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌的主要类型,相关位点突变检测研究已经成为肺癌分子靶向治疗的热门方向,研究NSCLC肿瘤组织中动物微管相关蛋白4与间变性淋巴瘤激酶融合基因(echinodem microtubule associated protein like 4-Anaplastic lymphoma kinase, EML4-ALK)与表皮生长因子受体(epidermal growth factor receptor, EGFR)的基因突变状态,比较免疫组织化学(immunohistochemistry, IHC)与蝎形探针扩增阻滞突变系统(Scorpions amplification refractory mutation system, Scorpions ARMS)荧光定量PCR与荧光原位杂交(fluorescence in situ hybridization, FISH)检测EML4-ALK融合基因与EGFR基因突变的敏感性。. The gene discussed is ALK; the disease is non-small cell lung carcinoma.