NPHS2 and nephrosis: Shono et al. (2007) demonstrated that podocin co-localizes with the coxsaxie virus and adeno virus receptor (CAR) and with ZO-1 at the tight junction between foot processes in puromycin aminonucleoside (PA) nephrosis (PAN) rat kidneys and podocin facilitated the coalescence of lipid rafts containing CAR and makes dynamic cytoskeletal arrangement.