However, it appears that CIN85 must associate with Cbl in order to regulate intracellular signaling such as the antigen receptor signaling in human B cells [12], interaction and modulation of TRAIL-induced MEKK4/p38/Akt survival network [13], and mono-ubiquitination of AMAP1 to drive invasion of breast cancer cells [14]. The gene discussed is SH3KBP1; the disease is breast carcinoma.