For example, (1) abnormal expression of human RPL7 and RPL13a interfere with cell cycle progression and induce apoptosis, interacting with Mdm2, a ubiquitin ligase that checks on p53 levels; (2) Many eukaryotic ribosomal proteins (S7, S19, L5, L22 and L23) are involved in p53-mediated apoptosis; (3) in humans, RPS3 induces caspase-dependent apoptosis, and some of ribosomal proteons involved in apoptosis are over-expressed in cancer cells (reviewed in [1]). Here, TP53 is linked to cancer.