RET and ischemia: Interestingly, in the core region, the downregulation of the mature form of Ret51, with 170 kDa, was accompanied by an increase in the abundance of a 150 kDa protein that is likely to correspond to an immature form of the protein present in the endoplasmic reticulum.41, 42 These results show a comparable pattern of change in Ret51 protein levels following excitotoxic stimulation (Figures 1b and c) and in both ischemia models used in this work (Figures 4a and b, and Figure 5c).