BASP1 and hypertensive nephropathy: This hypothesis might explain the observation of BASP1-positive and -negative tubules in human diabetic nephropathy and experimental diabetic and hypertensive nephropathies.19 Tubules belonging to a nephron where podocyte injury has resulted in glomeruloesclerosis and more severe albuminuria would be expected to express more BASP1 than tubules from nephrons with more preserved functional podocytes.