TNF and Alzheimer disease: BRAAK staging describes the amount and distribution of neurofibrillary tangles (NFT).25 This postmortem analysis is widely used because it has been found to correlate well with the severity of dementia.26, 27, 28 As FAIM-L is expressed only in neurons and has been described as an antagonist of TNFα-induced death,23 we focused on the role of this protein in AD.