PAK1 and cancer: Resistance to anoikis program represents a molecular basis for cancer progression and drug resistance.15, 17 The regulation of phosphorylation and function of Snail by PAK1 signaling kinase may contribute to the process of epithelial–mesenchymal transition (EMT) that plays a pivotal role in the conversion of early-stage tumors into invasive malignancies.18 EMT induction in cancer cells results in the acquisition of stem-like phenotype and drug resistance trait.19, 20