The molecular events linking intrinsic (e.g., levels of transcription factors, signaling pathways) with extrinsic influences (e.g., host factors, microenvironment, immune response) may play an important role in rendering stem-like phenotype of cancer cells with the ability to modulate tumorigenicity and drug responses.47, 48 Our present study suggested that PAK1 signaling had an impact on cancer cell behavior and stem-like phenotype. Here, PAK1 is linked to cancer.