Tone and colleagues analyzed 94 samples from childhood ALL patients, of which 78 corresponded to B-ALL and only 4 had a pro-B-ALL immunophenotype.34 In the present work, we took advantage of a data set obtained in an integrative epigenomic study where they analyzed adult B-ALL patients distinguishing different immunophenotypes.35 Performing an accurate analysis of the expression of HDAC7, we found that HDAC7 was significantly underexpressed in pro-B-ALL patients. The gene discussed is HDAC7; the disease is precursor B-cell acute lymphoblastic leukemia.