HDAC7 and hematopoietic and lymphoid cell neoplasm: Of the various HDACs, HDAC7 appears to be a lymphoid-specific transcriptional repressor.20, 21, 22, 23, 24, 25, 26 In addition to its critical role in T lymphocyte biology, we have recently reported that HDAC7 is critical in maintaining the genetic identity of B lymphocytes.20 Interestingly, HDAC7 has been identified as a target gene in hematopoietic cancers in a PiggyBac transposon mutagenesis screening in mice.27 On the basis of our recent findings, we postulated that HDAC7 might be deregulated in B-cell malignancies.