PPP1R13L and melanoma: Our results, arguing that iASPP acts in a pro-apoptotic manner at least in a subset of tumors, should give rise to caution toward the previously proposed strategy of using iASPP as an anti-cancer drug target.11, 37 On the other hand, it may be promising to mimic the pro-apoptotic actions of iASPP in situations where it is silenced, especially in melanomas.