EP300 and melanoma: BRMS1 is known as a suppressor of metastasis (but not of primary tumor progression), presumably through its interaction with the mSIN3a repressor complex.38 Accordingly, high cytoplasmic BRMS1 levels represent a favorable prognostic marker regarding the clinical course of melanoma patients,39 whereas nuclear BRMS1 staining correlates with a reduced overall survival rate.40 We propose that BRMS1 still antagonizes p300/CBP-mediated apoptosis in this tumor; however, this function may be carried out even by small amounts of BRMS1, since its antagonist iASPP is largely absent.