EP300 and cutaneous melanoma: In line with our proposed model of iASPP-mediated inhibition of p300/CBP degradation, immunohistochemical analysis revealed a significant decline in the nuclear protein levels of CBP and iASPP in 9 primary melanomas and 5 cutaneous melanoma metastases, compared with 11 benign melanocytic nevi (Figure 6d, Supplementary Figures S6B, C, S7A and B).